Evaluation of circulating miRNAs and mRNAs expression patterns in autism spectrum disorder

Abstract Background Autism spectrum disorder is a condition related to brain development that affects person’s perception and socialization, resulting in problems social interaction communication. It has no single known cause, yet several different genes appear be involved autism. As genetically complex disease, dysregulation of miRNA expression miRNA–mRNA interactions might feature autism disorder. The aim the current study was investigate profile circulating miRNA-128, miRNA-7 SHANK gene family ASD patients assess possible influence miRNA-128 on genes, which provide an insight into pathogenic mechanisms introduce noninvasive molecular biomarkers for disease diagnosis prognosis. Quantitative real-time PCR technique employed determine levels blood samples 40 autistic cases along with 30 age- sex-matched normal volunteer subjects. Results Our revealed statistical significant upregulation compared controls ( p value < 0.001). A difference SHANK-3 encountered comparing However, showed between studied groups. Conclusions MiRNA-128 are emerging players field ASD. They promising candidates as Future studies needed emphasize their pivotal role.